Publications

Pyle CJ, Uwadiae FI, Swieboda DP, Harker JA. Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology. PLoS Pathogens. 2017 Sep; 13(9)e1006640. https://doi.org/10.1371/journal.ppat.1006640

 

Zuniga EI, Macal M, Lewis GM, Harker JA. Innate and Adaptive Immune Regulation During Chronic Viral Infections. Annu Rev Virol. 2015 Nov;2(1):573-97. doi: 10.1146/annurev-virology-100114-055226. Review. PubMed PMID: 26958929; PubMed Central PMCID: PMC4785831.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785831/

 

 

Taylor A, Harker JA, Chanthong K, Stevenson PG, Zuniga EI, Rudd CE. Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses. Immunity. 2016 Feb 16;44(2):274-86. doi: 10.1016/j.immuni.2016.01.018. PubMed PMID: 26885856; PubMed Central PMCID: PMC4760122. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760122/

 

 

Lloyd CM, Harker JA. Location, Location, Location: Localized Memory Cells Take Residence in the Allergic Lung. Immunity. 2016 Jan 19;44(1):13-5. doi: 10.1016/j.immuni.2015.12.012. PubMed PMID: 26789918. http://www.cell.com/immunity/fulltext/S1074-7613(15)00538-5

 

 

Harker JA, Wong KA, Dolgoter A, Zuniga EI. Cell-Intrinsic gp130 Signaling on CD4+ T Cells Shapes Long-Lasting Antiviral Immunity. J Immunol. 2015 Aug 1;195(3):1071-81. doi: 10.4049/jimmunol.1402402. PubMed PMID: 26085685; PubMed Central PMCID: PMC4506854. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506854/

 

Harker JA, Yamaguchi Y, Culley FJ, Tregoning JS, Openshaw PJ. Delayed sequelae of neonatal respiratory syncytial virus infection are dependent on cells of the innate immune system. J Virol. 2014 Jan;88(1):604-11. doi: 10.1128/JVI.02620-13. PubMed PMID: 24173217; PubMed Central PMCID: PMC3911760.

 

Harker JA, Dolgoter A, Zuniga EI. Cell-intrinsic IL-27 and gp130 cytokine receptor signaling regulates virus-specific CD4⁺ T cell responses and viral control during chronic infection. Immunity. 2013 Sep 19;39(3):548-59. doi: 10.1016/j.immuni.2013.08.010. PubMed PMID: 23993651; PubMed Central PMCID: PMC4701058

 

Tregoning JS, Wang BL, McDonald JU, Yamaguchi Y, Harker JA, Goritzka M, Johansson C, Bukreyev A, Collins PL, Openshaw PJ. Neonatal antibody responses are attenuated by interferon-γ produced by NK and T cells during RSV infection. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5576-81. doi: 10.1073/pnas.1214247110. PubMed PMID: 23509276; PubMed Central PMCID: PMC3619373.

 

Zuniga EI, Harker JA. T-cell exhaustion due to persistent antigen: quantity not quality? Eur J Immunol. 2012 Sep;42(9):2285-9. doi: 10.1002/eji.201242852. PubMed PMID: 22949327; PubMed Central PMCID: PMC3684559.

 

Yamaguchi Y, Harker JA, Wang B, Openshaw PJ, Tregoning JS, Culley FJ. Preexposure to CpG protects against the delayed effects of neonatal respiratory syncytial virus infection. J Virol. 2012 Oct;86(19):10456-61. doi: 10.1128/JVI.01082-12. PubMed PMID: 22811525; PubMed Central PMCID: PMC3457284.

 

Macal M, Lewis GM, Kunz S, Flavell R, Harker JA, Zúñiga EI. Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection. Cell Host Microbe. 2012 Jun 14;11(6):617-30. doi: 10.1016/j.chom.2012.04.017. PubMed PMID: 22704622; PubMed Central PMCID: PMC3377983.

 

Harker JA, Lewis GM, Mack L, Zuniga EI. Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science. 2011 Nov 11;334(6057):825-9. doi: 10.1126/science.1208421. PubMed PMID: 21960530;PubMed Central PMCID: PMC3388900.

 

Telcian AG, Laza-Stanca V, Edwards MR, Harker JA, Wang H, Bartlett NW, Mallia P, Zdrenghea MT, Kebadze T, Coyle AJ, Openshaw PJ, Stanciu LA, Johnston SL. RSV-induced bronchial epithelial cell PD-L1 expression inhibits CD8+ T cell nonspecific antiviral activity. J Infect Dis. 2011 Jan 1;203(1):85-94. doi: 10.1093/infdis/jiq020. Erratum in: J Infect Dis. 2012 Apr;205(7):1180. PubMed PMID: 21148500; PubMed Central PMCID: PMC3086441.

 

Tregoning JS, Yamaguchi Y, Wang B, Mihm D, Harker JA, Bushell ES, Zheng M, Liao G, Peltz G, Openshaw PJ. Genetic susceptibility to the delayed sequelae of neonatal respiratory syncytial virus infection is MHC dependent. J Immunol. 2010 Nov 1;185(9):5384-91. doi: 10.4049/jimmunol.1001594. PubMed PMID: 20921522.

 

Lee DC, Harker JA, Tregoning JS, Atabani SF, Johansson C, Schwarze J, Openshaw PJ. CD25+ natural regulatory T cells are critical in limiting innate and adaptive immunity and resolving disease following respiratory syncytial virus infection. J Virol. 2010 Sep;84(17):8790-8. doi: 10.1128/JVI.00796-10. PubMed PMID: 20573822; PubMed Central PMCID: PMC2919030.

 

Harker JA, Lee DC, Yamaguchi Y, Wang B, Bukreyev A, Collins PL, Tregoning JS, Openshaw PJ. Delivery of cytokines by recombinant virus in early life alters the immune response to adult lung infection. J Virol. 2010 May;84(10):5294-302. doi: 10.1128/JVI.02503-09. PubMed PMID: 20200251; PubMed Central PMCID: PMC2863826.

 

Harker JA, Godlee A, Wahlsten JL, Lee DC, Thorne LG, Sawant D, Tregoning JS, Caspi RR, Bukreyev A, Collins PL, Openshaw PJ. Interleukin 18 coexpression during  respiratory syncytial virus infection results in enhanced disease mediated by natural killer cells. J Virol. 2010 Apr;84(8):4073-82. doi: 10.1128/JVI.02014-09. PubMed PMID: 20130064; PubMed Central PMCID: PMC2849516.

 

Pribul PK, Harker J, Wang B, Wang H, Tregoning JS, Schwarze J, Openshaw PJ. Alveolar macrophages are a major determinant of early responses to viral lung infection but do not influence subsequent disease development. J Virol. 2008 May;82(9):4441-8. doi: 10.1128/JVI.02541-07. PubMed PMID: 18287232; PubMed Central PMCID: PMC2293049.

 

Tregoning JS, Yamaguchi Y, Harker J, Wang B, Openshaw PJ. The role of T cells in the enhancement of respiratory syncytial virus infection severity during adult reinfection of neonatally sensitized mice. J Virol. 2008 Apr;82(8):4115-24. doi: 10.1128/JVI.02313-07. PubMed PMID: 18272579; PubMed Central PMCID: PMC2293007.

 

Harker J, Bukreyev A, Collins PL, Wang B, Openshaw PJ, Tregoning JS. Virally delivered cytokines alter the immune response to future lung infections. J Virol. 2007 Dec;81(23):13105-11. PubMed PMID: 17855518; PubMed Central PMCID: PMC2169117.

 

Openshaw PJ, Tregoning J, Harker J. RSV 2005: Global impact, changing concepts, and new challenges. Viral Immunol. 2005;18(4):749-51. PubMed PMID: 16359242.

 

Wiles S, Clare S, Harker J, Huett A, Young D, Dougan G, Frankel G. Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium. Cell Microbiol. 2004 Oct;6(10):963-72. Erratum in: Cell Microbiol. 2005 Mar;7(3):459. PubMed PMID: 15339271.